Gold nanoparticle-based gene delivery: promises and challenges

Nanotechnology Reviews

article

Remant Bahadur K.C.¹  Bindu Thapa¹  Narayan Bhattarai² 

[1] Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina;Department of Chemical, and Engineering Research Center- Revolutionized Metallic Biomaterials, North Carolina A&T State University

关键词: bioconjugation;    functionalization;    gene delivery;    gold nanoparticles;   

DOI  :  10.1515/ntrev-2013-0026

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Gold nanoparticles have emerged as a promising material for biomedical research due to ease of synthesis and highly adjustable optical properties, which can be utilized in the imaging of different diseases. Gold nanoparticles are fabricated by grafting biocompatible polymers and natural or synthethic biomolecules and present a novel avenue for engineering multifunctional smart systems. Many reports on the significant achievements and the bioconjugation chemistry promise to expand the application spectrum of gold nanoparticles. This review summarizes the current state-of-the-art development of functionalized gold nanoparticles for cancer gene therapy.

【 授权许可】

CC BY