Microfluidic-assisted synthesis and modelling of monodispersed magnetic nanocomposites for biomedical applications

Nanotechnology Reviews

article

Omid Sartipzadeh¹  Seyed Morteza Naghib¹  Farhad Shokati²  Mehdi Rahmanian²  Keivan Majidzadeh-A²  Yasser Zare²  Kyong Yop Rhee³ 

[1] Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology;Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute;Department of Mechanical Engineering, College of Engineering, Kyung Hee University

关键词: microfluidic device;    nanocomposite droplet;    cell isolation;    tumour modelling;    experimental validation;    lab-on-a-chip;   

DOI  :  10.1515/ntrev-2020-0097

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Droplet microfluidic was devoted to design and fabricate robust devices in the field of biosensing, tissue engineering, drug delivery, cell encapsulation, cell isolation, and lab-on-a-chip. Chitosan was widely used for different biomedical applications because of its unique characteristics such as antibacterial bioactivities, immune-enhancing influences, and anticancer bioactivities. In this research, a model is used for investigating the formation and size of composite droplets in a microfluidic device. The role of the velocity flow ratio in the composite droplet characteristics such as the generation rate and composite droplet size is described. According to the results, a desirable protocol is developed to control the properties of the composite droplets and to compare the size and rate of the composite droplets in a micro device. Furthermore, the level set laminar two-phase flow approach is exploited for studying the composite droplet-breaking procedure. An experimental procedure is used for validation of the simulation process. Various sizes and geometries of the composite droplets are fabricated to depict a potential in biomedical applications such as bioimaging, biosensing, tissue engineering, drug delivery, cell encapsulation, cancer cell isolation, and lab-on-a-chip.

【 授权许可】

CC BY