Degradation modeling of poly- l -lactide acid (PLLA) bioresorbable vascular scaffold within a coronary artery

Nanotechnology Reviews

article

Shengmao Lin¹  Hiram G. Bezerra²  Linxia Gu³  Pengfei Dong³  Changchun Zhou⁴  Luis Augusto P. Dallan⁵  Vladislav N. Zimin⁵  Gabriel T. R. Pereira⁵  Juhwan Lee⁶  Yazan Gharaibeh⁶  David L. Wilson⁶ 

[1] School of Civil Engineering and Architecture, Xiamen University of Technology;Interventional Cardiology Center, Heart and Vascular Institute, University of South Florida, United States of America;Department of Biomedical and Chemical Engineering, Florida Institute of Technology, United States of America;National Engineering Research Center for Biomaterials, Sichuan University;Cardiovascular Imaging Core Laboratory, Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, United States of America;Department of Biomedical Engineering, Case Western Reserve University, United States of America

关键词: bioresorbable vascular scaffold;    stent;    poly-l-lactide acid;    degradation;    coronary artery;    finite element method;    percutaneous coronary intervention;   

DOI  :  10.1515/ntrev-2020-0093

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

In this work, a strain-based degradation model was implemented and validated to better understand the dynamic interactions between the bioresorbable vascular scaffold (BVS) and the artery during the degradation process. Integrating the strain-modulated degradation equation into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both strut thinning and discontinuity of the stent struts within an artery were captured and visualized. The predicted results in terms of mass loss and fracture locations were validated by the documented experimental observations. In addition, results suggested that the heterogeneous degradation of the stent depends on its strain distribution following deployment. Degradation is faster at the locations with higher strains and resulted in the strut thinning and discontinuity, which contributes to the continuous mass loss, and the reduced contact force between the BVS and artery. A nonlinear relationship between the maximum principal strain of the stent and the fracture time was obtained, which could be transformed to predict the degradation process of the BVS in different mechanical environments. The developed computational model provided more insights into the degradation process, which could complement the discrete experimental data for improving the design and clinical management of the BVS.

【 授权许可】

CC BY