Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Nanotechnology Reviews

article

Xinyi Gu¹  Xiaoli Chen¹  Xiaoxuan Tang¹  Zhihao Zhou¹  Tingting Huang¹  Yumin Yang¹  Jue Ling¹ 

[1] Key Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University

关键词: silk fibroin;    hydrogel;    micropattern;    peripheral nerve regeneration;   

DOI  :  10.1515/ntrev-2021-0002

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration.

【 授权许可】

CC BY