Nanoparticle-functionalized microcapsules for in vitro delivery and sensing

Nanophotonics

article

Susana Carregal-Romero¹  Markus Ochs¹  Wolfgang J. Parak¹ 

[1] Philipps Universität Marburg

关键词: polyelectrolyte capsules;    colloidal nanoparticles;    quantum dots;    magnetic nanoparticles;    plasmonic nanoparticles;    multifunctionality;    delivery system;    sensors;    hybrid particles;   

DOI  :  10.1515/nanoph-2012-0014

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Inorganic nanoparticles such as magnetic nanoparticles, fluorescent quantum dots, and plasmonic nanoparticles can be used as building blocks for designing multifunctional systems based on polymeric capsules. The properties of the inorganic nanoparticles hereby are harnessed to provide additional functionality to the polymer capsules. Biological applications towards in vitro sensing and delivery are discussed. Examples will be given in which magnetic nanoparticles are used to direct capsules with magnetic field gradients, colloidal quantum dots are used to identify capsules via the formation of optical barcodes, and gold nanoparticles are used as light-controlled heat-sources for opening capsules and releasing macromolecules from their cavity upon optical excitation. This demonstrates that combination of inorganic nanoparticles and organic/polymeric molecules as carrier matrices allow for tailoring multifunctional hybrid particles for practical applications.

【 授权许可】

CC BY