Optofluidic bioanalysis: fundamentals and applications

Nanophotonics

article

Damla Ozcelik¹  Hong Cai¹  Kaelyn D. Leake¹  Aaron R. Hawkins²  Holger Schmidt¹ 

[1] School of Engineering, University of California-Santa Cruz;ECEn Department, Brigham Young University

关键词: biosensing;    integrated optics;    lab-on-chip;    optofluidics;    photonics;   

DOI  :  10.1515/nanoph-2016-0156

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Abstract: Over the past decade, optofluidics has established itself as a new and dynamic research field for exciting developments at the interface of photonics, microfluidics, and the life sciences. The strong desire for developing miniaturized bioanalytic devices and instruments, in particular, has led to novel and powerful approaches to integrating optical elements and biological fluids on the same chip-scale system. Here, we review the state-of-the-art in optofluidic research with emphasis on applications in bioanalysis and a focus on waveguide-based approaches that represent the most advanced level of integration between optics and fluidics. We discuss recent work in photonically reconfigurable devices and various application areas. We show how optofluidic approaches have been pushing the performance limits in bioanalysis, e.g. in terms of sensitivity and portability, satisfying many of the key requirements for point-of-care devices. This illustrates how the requirements for bianalysis instruments are increasingly being met by the symbiotic integration of novel photonic capabilities in a miniaturized system.

【 授权许可】

CC BY