Simple and efficient synthesis of novel N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazines

Heterocyclic communications

article

Ying Fu¹  Li-Hua Qu¹  Shan-Shan Zhang¹  Fei Ye¹  Li-Xia Zhao¹  Shuang Gao¹  Zhi-Yong Xing¹ 

[1] Department of Applied Chemistry, Northeast Agricultural University

关键词: acylation;    cycloaddition;    N-dichloroacetyl-3;    4-dihydro-2H-1;    4-benzoxazine;    synthesis;   

DOI  :  10.1515/hc-2012-0056

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

An easy synthetic route to N -dichloroacetyl-3,4-dihydro-2 H -1,4-benzoxazine derivatives 3 involves cyclization of 2-aminophenols 1 with 1,2-dibromoethane and subsequent acylation of the resultant 3,4-dihydro-2 H -1,4-benzoxazine derivatives 2 with dichloroacetyl chloride. All compounds were characterized by IR, 1 H NMR, 13 C NMR, ESI-MS and elemental analysis. The structure of 3a was determined by X-ray crystallographic analysis.

【 授权许可】

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