Poly(ethylene)glycol/AlCl3 as a new and efficient system for multicomponent Biginelli-type synthesis of pyrimidinone derivatives

Heterocyclic communications

article

Ali Amoozadeh¹  Salman Rahmani¹  Firouzeh Nemati¹ 

[1] Faculty of Chemistry, Department of Organic Chemistry, Semnan University

关键词: aluminum chloride;    Biginelli condensation;    poly(ethylene)glycol;    pyrimidinone;   

DOI  :  10.1515/hc-2012-0157

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Biginelli condensation of aldehydes, cyclopentanone and urea or thiourea in poly(ethylene)glycol 400, at 45°C in the presence of aluminum chloride as a highly efficient catalyst has been developed. The reaction is very fast, clean and environmentally benign for the synthesis of a vast variety of pyrimidinone derivatives.

【 授权许可】

CC BY|CC BY-NC-ND