Improved synthesis of 6-[(ethylthio)methyl]-1H-indazole

Heterocyclic communications

article

Agnès M. Sirven¹  Roman Stefak¹  Gwénaël Rapenne¹ 

[1] CEMES-CNRS;Université de Toulouse

关键词: bromide;    indazoles;    mesylate;    protecting groups;   

DOI  :  10.1515/hc-2014-0180

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

In the improved synthesis of 6-[(ethylthio)methyl]-1 H -indazole ( 5 ), the mesylate intermediate is replaced by the bromide derivative, which increases the overall yield (six steps) by a factor of 3.

【 授权许可】

CC BY|CC BY-NC-ND