One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles

Molecules

Gary W. Breton¹ 

[1] Department of Chemistry, Berry College, PO Box 495016, Mount Berry, GA 30101, USA

关键词: 2;    3-dihydro-1H-indazole;    synthesis;    heterocycle;    indazoles;    copper coupling;   

DOI  :  10.3390/molecules16119553

来源: mdpi

【 摘 要 】

A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.