Montmorillonite K10 catalyzed multi component reactions (MCR): synthesis of novel thiazolidinones as anticancer agents

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Ganapavarapu Veera Raghava Sharma¹  Bandaru Devi¹  Karri Someswara Reddy¹  Mallidi Veeraghava Reddy¹  Anand Kumar Kondapi²  Cherukuvada Bhaskar² 

[1] Department of Chemistry, GITAM University;Department of Biotechnology, University of Hyderabad

关键词: anticancer agents;    campholenic aldehyde;    montmorillonite K10;    multi component reaction (MCR);    thiazolidinone;   

DOI  :  10.1515/hc-2015-0035

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Montmorillonite K10 is a suitable catalyst in a multicomponent reaction involving an aldehyde, an amine, and thioglycolic acid in N , N -dimethylformamide as solvent at moderate (50°C) to reasonably high (120°C) temperatures to form thiazolidinones. The reaction involves easy workup and purification. Several thiazolidinones were prepared. In particular, campholenic aldehyde obtained from α-pinene was used to synthesize potentially bioactive thiazolidinones. All products were characterized by IR, 1 H NMR, and mass spectra. Preliminary anticancer screening tests revealed that two compounds show anticancer activity and can be taken up for further screening.

【 授权许可】

CC BY|CC BY-NC-ND