Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds

Molecules

Hatice Başpınar Küçük¹  Ayşe Yusufoğlu¹  Emel Mataracı¹ 

[1] ¹Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey ²Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Bayezit, Istanbul, Turkey

关键词: 1;    3-dioxolanes;    montmorillonite K10;    diols;    antibacterial activity;    antifungal activity;   

DOI  :  10.3390/molecules16086806

来源: mdpi

【 摘 要 】

A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.