TiCl2·2H2O catalyzed one-pot synthesis of highly functionalized tetrahydropiperidines and evaluation of their antimicrobial activities

Heterocyclic communications

article

Mohsen Abbasi¹  Seyed Mohammad Seyedi¹  Hamid Sadeghian²  Maryam Akhbari³  Mohammadreza Enayaty³  Ali Shiri¹ 

[1] Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad;Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences;Department of Phytochemistry, Essential Oil Research Institute, University of Kashan

关键词: antibacterial activity;    multicomponent reaction;    TiCl2;    2H2O;    tetrahydropiperidine;   

DOI  :  10.1515/hc-2015-0081

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

One-pot condensation reaction of ethyl acetoacetate, various substituted benzaldehydes and anilines in the presence of TiCl 2 ·2H 2 O yields highly functionalized tetrahydropiperidines. Atom economy, efficiency, and short reaction times are the advantages of the method, which is carried out under mild conditions using easily accessible and inexpensive chemicals. The antimicrobial activity of the synthesized products was evaluated against three Gram-positive and three Gram-negative bacteria, a yeast and a fungus strain using disc diffusion and minimum inhibitory concentration methods.

【 授权许可】

CC BY|CC BY-NC-ND