Heterocyclic communications | |
One-pot synthesis of new triazole-sucrose derivatives via click chemistry and evaluation of their antitubercular activity | |
article | |
Khaoula Hajlaoui1  Ahlem Guesmi2  Naoufel Ben Hamadi1  Moncef Msaddek1  | |
[1] Laboratory of Synthesis of Heterocyclic and Natural Substances, Department of Chemistry, Faculty of Sciences of Monastir;Chemistry Department, College of Science, IMSIU (Al Imam Mohammad Ibn Saud Islamic University) | |
关键词: carbohydrates; copper nanoparticles; cycloaddition; heterogeneous catalysis; Mycobacterium tuberculosis; triazoles; | |
DOI : 10.1515/hc-2016-0028 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
Readily prepared copper nanoparticles are an effective catalyst for 1,3-dipolar cycloaddition of carbohydrate azide and a variety of alkynes that furnishes the corresponding 1,2,3-triazole-sucrose derivatives in excellent yields. Products were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain. Two compounds, 3b , c , demonstrate significant growth inhibitory activity against the bacterial strain with a MIC of 3.125 mg/mL. The presence of an amide group on the 1,2,3-triazole ring enhances the inhibition activity of the molecules. The active compounds are not toxic to a normal cell line which signifies the lack of general cellular toxicity of these compounds.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107200002385ZK.pdf | 168KB | download |