Mono- and bis-dipicolinic acid heterocyclic derivatives – thiosemicarbazides, triazoles, oxadiazoles and thiazolidinones as antifungal and antioxidant agents

Heterocyclic communications

article

Maja Molnar¹  Valentina Pavić²  Bojan Šarkanj¹  Milan Čačić¹  Dubravka Vuković³  Jelena Klenkar¹ 

[1] Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology Osijek;Josip Juraj Strossmayer University of Osijek, Department of Biology;Microbiology Service of the Public Health, Institute of Osijek-Baranja County

关键词: antifungal;    antioxidant activity;    dipicolinic acid;    oxadiazole;    thiadiazole;    thiazolidinone;    triazole;   

DOI  :  10.1515/hc-2016-0078

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A series of dipicolinic acid derivatives was synthesized and investigated for antimicrobial and antioxidant activity. Mono and bis derivatives of ethyl dipicolinate were utilized as starting materials for synthesis of mono- and bis-hydrazides. Thiosemicarbazides were obtained by reaction of hydrazides with isothiocyanates and cyclized into triazoles, thiadiazoles, oxadiazoles and thiazolidinones. Some of these products, especially those incorporating a thiazolidinone moiety in their structure, are excellent antioxidants, DPPH scavengers and antifungal agents.

【 授权许可】

CC BY|CC BY-NC-ND