Isolation and biological activities of 3-hydroxy-4(1H)-pyridone

Journal of plant interactions

article

Tran Dang Xuan¹  Truong Ngoc Minh¹  Tran Dang Khanh² 

[1] Division of Development Technology, Graduate School for International Development and Cooperation (IDEC), Hiroshima University;Agricultural Genetics Institute

关键词: Mimosine;    3;    4-DHP;    inhibition;    antifungal;    antioxidant activity;    degradation;   

DOI  :  10.1080/17429145.2015.1135256

学科分类：纳米科学和纳米技术

来源: Taylor & Francis

【 摘 要 】

3-Hydroxy-4(4H)-pyridone (3,4-DHP), a degraded product of mimosine [β-[N-(3-hydroxy-4- oxypyridyl)]-α-aminopropionic acid], is known to cause goiters, loss of hair, and infertility in animals, but limits of 3,4-DHP on separation and purification have prevented efforts on investigating other toxicity and biological properties of 3,4-DHP. By this study, a novel and simple isolation of 3,4-DHP was developed either from Leucaena leaves using an ion-exchanged resin or mimosine degraded in high temperature (110°C, 6 h). The inhibition of mimosine on the growth of barnyardgrass was approximately fourfold higher (IC50 = 0.04 mg g−1 ) than that of 3,4-DHP (IC50 = 0.15 mg g−1 ). In general, the antifungal activity of mimosine is much stronger than that of 3,4-DHP, but it differs depending on the kind of fungi. The 1,1-diphyenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of 3,4-DHP, in contrast with the growth inhibitory activity, is about fourfold stronger [EC50 = 2.4 mg g−1 gallic acid equivalent (GAE)] than that of mimosine [EC50 = 10.3 mg g−1 GAE]. This study is the first to report on the herbicidal, antifungal, and antioxidant activities of 3,4-DHP.

【 授权许可】

CC BY|CC BY-NC