Impact of modified ribose sugars on nucleic acid conformation and function

Heterocyclic communications

article

Marina Evich¹  Alexander M. Spring-Connell¹  Markus W. Germann¹ 

[1] Georgia State University, Department of Chemistry;Georgia State University, Department of Biology;Georgia State University, Neuroscience Institute

关键词: deoxyribose;    nucleic acids;    nucleic acid modification;    pseudorotation;    ribose;    sugar conformation;   

DOI  :  10.1515/hc-2017-0056

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

The modification of the ribofuranose in nucleic acids is a widespread method of manipulating the activity of nucleic acids. These alterations, however, impact the local conformation and chemical reactivity of the sugar. Changes in the conformation and dynamics of the sugar moiety alter the local and potentially global structure and plasticity of nucleic acids, which in turn contributes to recognition, binding of ligands and enzymatic activity of proteins. This review article introduces the conformational properties of the (deoxy)ribofuranose ring and then explores sugar modifications and how they impact local and global structure and dynamics in nucleic acids.

【 授权许可】

CC BY|CC BY-NC-ND