Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

Heterocyclic communications

article

Gang-qiang Wang¹  Li-li Yan²  Qiu-an Wang² 

[1] Non-power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology;College of Chemistry and Chemical Engineering, Hunan University

关键词: alkyne;    antiproliferative activity;    azide;    cycloaddition;    flavonoids;    glycosides;    1;    2;    3-triazole;   

DOI  :  10.1515/hc-2017-0241

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Sixteen flavonoid triazolyl glycosides 4–19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1–3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized compounds against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) in vitro was evaluated. Flavonoids 1 , 2 and flavonoid triazolyl glycosides 7 , 12 , 17 exhibit potent antiproliferative activity against these cancer cell lines.

【 授权许可】

CC BY|CC BY-NC-ND