Synthesis and fungicidal activities of perfluoropropan-2-yl-based novel quinoline derivatives

Heterocyclic communications

article

Zai Zhang¹  Xingliang Zheng²  Minhua Liu¹  Weidong Liu¹  Jun Xiang¹  Jianming Li¹  Zhong Li¹  Xingping Liu¹  Mingzhi Huang¹  Aiping Liu¹ 

[1] National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry;School of Chemistry and Biological Engineering, Changsha University of Science and Technology;Hunan Province Key Laboratory for Agrochemicals

关键词: perfluoropropan-2-yl-based quinoline derivatives;    synthesis;    fungicidal activity;    structure-activity relationship;   

DOI  :  10.1515/hc-2019-0002

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1 HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis . Especially, compound 8c displayed excellent activity with EC 50 value at 1.48 mg / L, which was better than that of the commercialized fungicide --- tebufloquin. The structure-activity relationship for these new compounds was also discussed.

【 授权许可】

CC BY|CC BY-NC-ND