Synthesis and fungicidal activity of novel imidazo[4, 5-b]pyridine derivatives

Heterocyclic communications

article

Daoxin Wu¹  Weidong Liu²  Aiping Liu²  Minhua Liu²  Zhong Li¹  Mingming Dang⁴  Xingping Liu²  Jianming Li²  Lu Huang²  Yeguo Ren²  Zai Zhang¹ 

[1] School of Chemistry and Biological Engineering, Changsha University of Science and Technology;National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry;Hunan Province Key Laboratory for Agrochemicals;Department of Resources and Environment, Hunan Nonferrous Metals Vocational and Technical College

关键词: fungicidal activity;    imidazo[4;    5-b]pyridine;    structure-activity relationship;    synthesis;   

DOI  :  10.1515/hc-2019-0003

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A series of novel imidazo[4,5- b ]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC 50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

【 授权许可】

CC BY|CC BY-NC-ND