A Facile and Catalyst-free Synthesis of Hexahydroacridine-1,8(2H,5H )-dione and Octahydroacridin-10(1H )-yl)thiourea Derivatives: Inter- and Intramolecular Aza-Michael addition

Heterocyclic communications

article

Nader Noroozi Pesyan¹  Narmin Akhteh¹  Hana Batmani¹  Barış Anıl²  Ertan Şahin² 

[1] Department of Organic Chemistry, Faculty of Chemistry, Urmia University;Department of Chemistry, Faculty of Science, Atatürk University

关键词: Cyclohexanedione;    Octahydro-1H-xanthene;    Acridine;    X-ray;    1D-Polymeric H-bond;   

DOI  :  10.1515/hc-2020-0005

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

An easy and convenient technique for the one-pot synthesis of novel compounds of hexahydroacridine-1,8(2 H ,5 H )-dione and octahydroacridin-10(1 H )-yl) thiourea derivatives has been developed by the reaction of the octahydro-1 H -xanthenes with hydroxylamine hydrochloride and thiosemicarbazide in ethylene glycol, which is a green solvent, under mild reaction conditions. IR, 1 H NMR, 13 C NMR spectrometry, and X-ray diffraction analysis were used to identify the structures of these compounds.

【 授权许可】

CC BY|CC BY-NC-ND