Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium

Green Processing and Synthesis

article

Ramesh A. Joshi¹  Rohini R. Joshi¹  Jagdish Tibhe²  Nayana T. Nivangune²  Amol A. Kulkarni² 

[1] Organic Chemistry Division, National Chemical Laboratory;Chemical Engineering and Process Development Division, National Chemical Laboratory

关键词: β-amino crotonate;    continuous flow synthesis;    Hantzsch synthesis;    microreactor;   

DOI  :  10.1515/gps-2011-0002

来源: De Gruyter

【 摘 要 】

Continuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on their suitability. Upon studying the feasibility of continuous flow synthesis of different β-amino crotonates, the synthesis of methyl amino crotonate in the presence of a recyclable and reusable homogeneous acid catalyst has been studied in detail. Tubular reactors were seen to overcome the heat and mass transfer limitations, thereby providing a simple device for even a pilot scale production. A similar approach can be used for the synthesis of other β-amino crotonates. The continuous flow synthesis approach for producing methyl amino crotonate, in the absence of any external solvent, makes it a green process technology.

【 授权许可】

CC BY