Microwave-assisted one-pot syntheses of 4-aminoquinazolines

Green Processing and Synthesis

article

Wenting Song¹  Shunli He¹  Zeli Yuan¹  Guangqing Yu¹  Di Wu¹  Qing Wu¹  Minqing Zhang¹  Yongzheng Chen¹  Qinghong Hu¹ 

[1] School of Pharmacy, Zunyi Medical University

关键词: 4-aminoquinazoline;    methodology;    microwave assisted;    one-pot syntheses;   

DOI  :  10.1515/gps-2015-0121

来源: De Gruyter

【 摘 要 】

A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives 3 , 4 , and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations.

【 授权许可】

CC BY