Molecules | |
Novel [99mTcN]2+ Labeled EGFR Inhibitors as Potential Radiotracers for Single Photon Emission Computed Tomography (SPECT) Tumor Imaging | |
Mingxia Zhao1  Hongyu Ning1  Man Feng1  Shilei Li1  Jin Chang1  | |
[1] id="af1-molecules-19-05508">Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, Chi | |
关键词: [99mTcN]2+ complex; 4-aminoquinazoline; EGFR; tumor imaging; | |
DOI : 10.3390/molecules19055508 | |
来源: mdpi | |
【 摘 要 】
The epidermal growth factor receptor (EGFR) is overexpressed in many cancers, including breast, ovarian, endometrial and non-small cell lung cancer. An EGFR-specific imaging agent could facilitate clinical evaluation of primary tumors or metastases. To achieve this goal, 4-(2-aminoethylamino)-6,7-dimethoxyquinazoline (ADMQ) was synthesized based on a 4-aminoquinazoline core and then conjugated with
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190026479ZK.pdf | 445KB | download |