Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application

Green Processing and Synthesis

article

Thi Bich Tram Nguyen¹  Ngoc Quyen Tran²  Le Hang Dang²  Thi Thanh Thuy Nguyen²  Dai Lam Tran⁴  Dai Hai Nguyen²  Van Toan Nguyen⁵  Cuu Khoa Nguyen²  Thi Hiep Nguyen⁶  Van Thu Le⁷ 

[1] Department of Natural Science, Thu Dau Mot University;Institute of Applied Materials Science, Vietnam Academy of Science and Technology;School of Biotechnology, International University, Viet Nam National University in HCMC;Vietnam Graduate University of Science and Technology, Vietnam Academy of Science and Technology;Department of Chemistry and Food Technology, Ba Ria-Vung Tau University;Biomedical Engineering Department, International University, Viet Nam National University in HCMC;Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security

关键词: biomedical application;    chitosan;    nanocurcumin;    thermosensitive copolymer;   

DOI  :  10.1515/gps-2016-0062

来源: De Gruyter

【 摘 要 】

In this study, in order to enhance the aqueous solubility and to overcome the limitation of curcumin (Cur) in free form, as well as to develop a carrier for transdermal delivery of hydrophobic pharmaceutical agents such as Cur, a sonicated synthetic process of nanocurcumin (nCur) in thermally responsive Chitosan-g-Pluronic (CP) copolymer is disclosed herein. The use of CP copolymer solution as a dispersant medium is a very attractive method to avoid the use of toxic organic solvent and non-biocompatible surfactant. The obtained Cur nanoparticles had a fairly narrow distribution of 8–23 nm. nCur-dispersed CP solution showed good stability with no change in color characteristic and no phase separation after 1 month of storage. Rheological characterization of CP hydrogels had indicated sol-gel transition at the same temperature (35°C). Interestingly, the rate of Cur release for this system can be conveniently modulated as transdermal drug delivery.

【 授权许可】

CC BY