An efficient and catalyst-free synthesis of N-arylidene-2-arylimidazo[1,2-a]pyridine-3-ylamine derivatives via Strecker reaction under controlled microwave heating

Green Processing and Synthesis

article

Afaf Mohamed Abdel Hameed¹  Moustafa Sherief Moustafa²  Saleh Mohammed Al-Mousawi²  Reham R. Awed¹  Kamal Usef Sadek¹ 

[1] Department of Chemistry, Faculty of Science, El-Minia University;Department of Chemistry, Faculty of Science, Kuwait University

关键词: catalyst free;    microwave heating;    multicomponent reaction;    N-aryldene-2-arylimidazo[1;    2-a]-pyridine-3-ylamine;    Strecker reaction;   

DOI  :  10.1515/gps-2017-0019

来源: De Gruyter

【 摘 要 】

An efficient one-pot multicomponent reaction of 2-aminopyridine with aromatic aldehydes and either benzoyl cyanide or cyanamide in pyridine under controlled microwave heating afforded N-aryldene-2-arylimidazo[1,2-a]-pyridine-3-ylamine derivatives. The reaction is catalyst free and is of high atom economy.

【 授权许可】

CC BY