An efficient green synthesis of novel 1 H -imidazo[1,2- a ]imidazole-3-amine and imidazo[2,1- c ][1,2,4]triazole-5-amine derivatives via Strecker reaction under controlled microwave heating

Green Processing and Synthesis

article

Kamal Usef Sadek¹  Afaf Mohamed Abdel-Hameed¹  Hisham A. Abdelnabi¹  Yasser Meleigy¹ 

[1] Chemistry Department, Faculty of Science, Minia University

关键词: catalyst free;    imidazo [1;    2-a]imidazoles;    imidazo[2;    1-c][1;    2;    4]triazoles;    microwave heating;    multi-component reaction;    Strecker reaction;   

DOI  :  10.1515/gps-2018-0093

来源: De Gruyter

【 摘 要 】

A highly efficient multi-component one-pot synthesis of novel 1 H -imidazo[1,2- a ]imidazole-3-amine and imidazo[2,1- c ][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.

【 授权许可】

CC BY