One-pot, three-component, selective synthesis of the polyfunctionalized 4 H -pyran and 4 H -benzo[ b ]pyran derivatives in the presence of a highly efficient molecular sieve-supported zinc catalyst

Green Processing and Synthesis

article

Ágnes Magyar¹  Zoltán Hell¹ 

[1] Department of Organic Chemistry and Technology, Budapest University of Technology and Economics

关键词: heterogeneous catalysis;    molecular sieve;    multicomponent reactions;    polyfunctionalized 4H-pyrans and 4H-benzo[b]pyrans;    zinc;   

DOI  :  10.1515/gps-2017-0083

来源: De Gruyter

【 摘 要 】

A series of pentasubstituted 4 H -pyrans and tetrahydrobenzo[ b ]pyrans are synthesized with excellent yields via a one-pot condensation of aromatic aldehydes, malononitrile, and a dicarbonyl compound, ethyl acetoacetate, acetyl-acetone or dimedone, in the presence of 4 Å molecular sieve modified with zinc(II) as heterogeneous catalyst, in ethanol. The process offers numerous advantages, such as better yield, short reaction time, and mild reaction conditions. The catalyst’s preparation is simple and it could be reused while still maintaining its activity.

【 授权许可】

CC BY