Volcanic ash as reusable catalyst in the green synthesis of 3 H -1,5-benzodiazepines

Green Processing and Synthesis

article

Mercedes Muñoz¹  Gustavo Pasquale²  Angel Gabriel Sathicq¹  Gustavo Pablo Romanelli³  Carmen Inés Cabello³  Delia Gazzoli⁵ 

[1] Centro de Investigación y Desarrollo en Ciencias Aplicadas ‘Dr. J. J. Ronco’, (CINDECA);Centro de Investigación en Sanidad Vegetal, (CISaV), Facultad de Ciencias Agrarias y Forestales UNLP. Calles;Centro de Investigación y Desarrollo en Ciencias Aplicadas ‘Dr. J. J. Ronco’, (CINDECA), CONICET;CIC-PBA Researcher - Facultad de Ingeniería;Dipartimento di Chimica, Università di Roma

关键词: volcanic ash;    benzodiazepines;    green chemistry;    heterogeneous catalysis;    solvent-free reaction;   

DOI  :  10.1515/gps-2019-0030

来源: De Gruyter

【 摘 要 】

The volcanic ash from the Andes mountain range (Puyehue-Cordon Caulle volcanic complex situated in western South America on the Argentinean-Chilean border) was used as heterogeneous acid catalyst in the suitable synthesis of 3 H -1,5-benzodiazepines. The natural ashes were classified according to their particle size to generate the different catalytic materials. The catalysts were characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), vibrational spectroscopies (FT-IR and Raman), and textural properties were determined by N 2 adsorption (S BET ). Potentiometric titration with n-butylamine was used to determine the acidic properties of the catalytic materials. Several 3 H -1,5-benzodiazepines were obtained by reaction of o -phenylenediamine and substituted 1,3-diphenyl-1,3-propanedione in solvent-free conditions, giving good to excellent yields of a variety benzodiazepines. The method was carried out in environmentally friendly conditions and it was operationally simple. The volcanic ash resulted in a safe and recyclable catalyst.

【 授权许可】

CC BY