Effects of Therapeutic Hypothermia on Normal and Ischemic Heart

Frontiers in Cardiovascular Medicine

Kelly P. Yamada¹  Tadao Aikawa¹  Taro Kariya¹  Kiyotake Ishikawa² 

[1]Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

[2]null

关键词: hypothermia;    myocardial infarction;    infarct size;    endovascular;    physiology;    cardiac function;    clinical trial;    preclinical;   

DOI  :  10.3389/fcvm.2021.642843

来源: Frontiers

【 摘 要 】

Therapeutic hypothermia has been used for treating brain injury after out-of-hospital cardiac arrest. Its potential benefit on minimizing myocardial ischemic injury has been explored, but clinical evidence has yet to confirm positive results in preclinical studies. Importantly, therapeutic hypothermia for myocardial infarction is unique in that it can be initiated prior to reperfusion, in contrast to its application for brain injury in resuscitated cardiac arrest patients. Recent advance in cooling technology allows more rapid cooling of the heart than ever and new clinical trials are designed to examine the efficacy of rapid therapeutic hypothermia for myocardial infarction. In this review, we summarize current knowledge regarding the effect of hypothermia on normal and ischemic hearts and discuss issues to be solved in order to realize its clinical application for treating acute myocardial infarction.

【 授权许可】

CC BY