The Key Role of Uric Acid in Oxidative Stress, Inflammation, Fibrosis, Apoptosis, and Immunity in the Pathogenesis of Atrial Fibrillation

Frontiers in Cardiovascular Medicine

Fei Liu¹  Yawen Deng¹  Xiaolei Yang²  Yunlong Xia² 

[1] Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, China;null;

关键词: uric acid;    atrial fibrillation;    mechanisms;    oxidative stress;    inflammation;   

DOI  :  10.3389/fcvm.2021.641136

来源: Frontiers

【 摘 要 】

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia that leads to numerous adverse outcomes including stroke, heart failure, and death. Hyperuricemia is an important risk factor that contributes to atrium injury and AF, but the underlying molecular mechanism remains to be elucidated. In this review, we discussed the scientific evidence for clarifying the role of hyperuricemia in the pathogenesis of AF. Experimental and Clinical evidence endorse hyperuricemia as an independent risk factor for the incidence of AF. Various in vivo and in vitro investigations showed that hyperuricemia might play a critical role in the pathogenesis of AF at different UA concentrations through the activation of oxidative stress, inflammation, fibrosis, apoptosis, and immunity.

【 授权许可】

CC BY