The Roles of the LIM Domain Proteins in Drosophila Cardiac and Hematopoietic Morphogenesis

Frontiers in Cardiovascular Medicine

Tingting Jiang¹  Meihua She²  Min Tang²  Qun Zeng² 

[1] Affiliated Nanhua Hospital, University of South China, Hengyang, China;Department of Biochemistry and Molecular Biology, College of Hengyang Medical, University of South China, Hengyang, China;

关键词: Drosophila melanogaster;    LIM domain;    cardiac;    hematopoietic;    development;   

DOI  :  10.3389/fcvm.2021.616851

来源: Frontiers

【 摘 要 】

Drosophila melanogaster has been used as a model organism for study on development and pathophysiology of the heart. LIM domain proteins act as adaptors or scaffolds to promote the assembly of multimeric protein complexes. We found a total of 75 proteins encoded by 36 genes have LIM domain in Drosophila melanogaster by the tools of SMART, FLY-FISH, and FlyExpress, and around 41.7% proteins with LIM domain locate in lymph glands, muscles system, and circulatory system. Furthermore, we summarized functions of different LIM domain proteins in the development and physiology of fly heart and hematopoietic systems. It would be attractive to determine whether it exists a probable “LIM code” for the cycle of different cell fates in cardiac and hematopoietic tissues. Next, we aspired to propose a new research direction that the LIM domain proteins may play an important role in fly cardiac and hematopoietic morphogenesis.

【 授权许可】

CC BY