Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2

Frontiers in Cardiovascular Medicine

Sang-Bing Ong¹  Yanhua Xu²  Mengqiu Ma²  Dachun Xu²  Yang Su²  Min Chai³  Xingdong Hu⁴  Yingjie Chen⁵  Maojun Zhao⁶  Hong Li⁷  Xiaojiang Xu⁸  Xiaojuan Fan⁹ 

[1] Centre for Cardiovascular Genomics and Medicine (CCGM), Lui Che Woo Institute of Innovative Medicine, Chinese University of Hong Kong (CUHK), Hong Kong, China;Hong Kong Hub of Paediatric Excellence (HK HOPE), Hong Kong Children's Hospital (HKCH), Hong Kong, China;Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong (CUHK), Hong Kong, China;Institute for Translational Medicine, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, China;Kunming Institute of Zoology–The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China;Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China;Department of Critical Care Medicine, Ezhou Central Hospital, Ezhou, China;Department of Critical Care Medicine, The Third people's Hospital of Guizhou Province, Guiyang, China;Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS, United States;Emergency Department, The First People's Hospital of Guiyang, Guiyang, China;Immunity, Inflammation & Disease Laboratory, The National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, United States;Kelly Government Solutions, Rockville, MD, United States;Key Laboratory of Environment and Genes Related to Diseases, Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

关键词: COVID-19;    SARS-CoV-2;    heart failure;    angiotensin converting enzyme 2;    single-cell RNA sequencing;   

DOI  :  10.3389/fcvm.2021.628885

来源: Frontiers

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