A pilot study of temsirolimus and body composition

Journal of Cachexia, Sarcopenia and Muscle

Veasey-Rodrigues Heloisa¹  Parsons Henrique A.¹  Janku Filip¹  Naing Aung¹  Wheler Jennifer J.¹  Tsimberidou Apostolia M.¹ 

[1] Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX

关键词: Temsirolimus;    Body composition;    Sarcopenia;    Toxicity;   

DOI  :  10.1007/s13539-013-0113-y

来源: Wiley

【 摘 要 】

Abstract

Purpose

Body weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss as one of its side effects.

Patients and methods

Sixteen patients with advanced solid tumors treated with temsirolimus were studied; body composition was evaluated utilizing computerized tomography images. Sarcopenia was defined as skeletal muscle index lower than 38.5 cm²/m² for women and 52.4 cm²/m² for men.

Results

Five of 16 patients (31 %) were men; median age, 60 years. Forty-four percent (7/16) of patients were sarcopenic. Fatigue, anemia, hyperglycemia, and hyperlipidemia were common. Baseline sarcopenia and body composition did not correlate with worse toxicity or treatment outcome. However, there was a trend for greater loss of adipose area (p = 0.07), fat mass (p = 0.09), and adipose index (p = 0.07) for patients with grade 3 or 4 toxicities versus those with grade 1 and 2 side effects.

Conclusion

Patients with higher grade toxicities tended to lose more body fat, suggesting a possible end-organ metabolic effect of temsirolimus. These observations merit exploration in a larger cohort of patients.

【 授权许可】

CC BY-NC   
© 2013 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.