Predicting type 2 diabetes using Sasang constitutional medicine

Journal of Diabetes Investigation

Nam H Cho¹  Jong Yeol Kim³  Sung Soo Kim⁴  Seung Ku Lee² 

[1] Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Korea;Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Korea;Division of Constitutional Medicine and Diagnosis Research Group, Korea Institute of Oriental Medicine, Daejeon, Korea;Korean National Genome Institute, The Korean Center for Disease Control and Prevention, Cheongwon-gun, Korea

关键词: Prospective study;    Sasang constitutional medicine;    Type 2 diabetes mellitus;   

DOI  :  10.1111/jdi.12189

来源: Wiley

【 摘 要 】

Abstract

Aims/Introduction

Sasang constitutional medicine (SCM) has existed in traditional Korean medicine for more than 100 years. SCM consists of four different types: So-Eum (SE), So-Yang (SY), Tae-Eum (TE) and Tae-Yang (TY). It is of great importance that the Sasang constitution type (SCT) be evaluated accurately and recognized by medical communities.

Materials and Methods

From the Ansung–Ansan prospective cohort study, 10,038 participants were recruited from the years 2001–2002. Of 10,038 original participants, 2,460 participants underwent SCT evaluation. The Cox proportional hazard model was used to predict diabetes during the 10-year follow-up period.

Results

During 10 years of follow up (22,007 person-years), 472 incidence cases (215/10,000 Incidence Density) of type 2 diabetes mellitus were documented. We identified that the TE group was significantly older, more obese, and had higher blood pressure, glucose metabolic values and lipid profiles levels. Relative risk (RR) and 95% confident intervals (CI) for type 2 diabetes were 1.696 (95% CI 1.204–2.39, P = 0.003) for TE when compared with the SE type. After controlling all potential confounders, the Cox proportional hazard model showed that RR was 1.635 (95% CI 1.111–2.406) in non-obese (body mass index <25) TE, and RR was 1.725 (95% CI 1.213–2.452) in obese (body mass index ≥25) TE when compared with the SE type. We did not find any differences when comparing SE and SY types. The findings shows that TE is a higher risk factor for type 2 Diabetes, independent of obesity level.

Conclusions

The present study suggests that the TE type, independent of obesity level, is a strong risk factor of type 2 diabetes.

【 授权许可】

CC BY-NC-ND   
© 2013 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

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