Factors influencing the durability of the glucose‐lowering effect of sitagliptin combined with a sulfonylurea

Journal of Diabetes Investigation

Akira Kubota⁴  Daisuke Yabe¹  Akira Kanamori²  Akira Kuroe³  Nobuo Takahashi⁶  Tatsuhiko Saito⁷  Ikuro Matsuba⁵  Koichiro Nabe⁴  Takeshi Kurose¹ 

[1] Kansai Electric Power Hospital, Osaka city, Osaka, Japan;Kanamori Diabetes Clinic, Sagamihara city, Kanagawa, Japan;Hikone Municipal Hospital, Hikone city, Shiga, Japan;Kubota Clinic of Internal Medicine, Kawasaki city, Kanagawa, Japan;Matsuba Clinic, Kawasaki city, Kanagawa, Japan;Takahashi Family Clinic, Nagoya city, Aichi, Japan;Kobari General Hospital, Noda city, Chiba, Japan

关键词: Blood glucose;    Sitagliptin;    Sulfonylurea;   

DOI  :  10.1111/jdi.12182

来源: Wiley

【 摘 要 】

Abstract

We analyzed the changes of glycemic control over 12 months and the factors influencing blood glucose in 162 Japanese patients with type 2 diabetes having inadequate glycemic control despite sulfonylurea-based therapy who received add-on sitagliptin. Hemoglobin A1c (HbA1c) decreased significantly after 4 weeks of treatment, and this improvement was maintained for 1 year, although HbA1c was slightly higher in week 52 than in week 24. Comparison of the patients showing a ≥0.4% increase of HbA1c between weeks 24 and 52 (n = 57) with the others (n = 105) showed a significant difference in the change of bodyweight, as well as the dose of glibenclamide (both P < 0.01). Although combined therapy with sitagliptin and a sulfonylurea seems to be effective for at least 1 year, blood glucose levels are more likely to increase again in patients who show greater weight gain after 24 weeks of treatment and those receiving a higher dose of glibenclamide.

【 授权许可】

CC BY-NC-ND   
© 2014 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

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