Adiponectin gene variants, adiponectin isoforms and cardiometabolic risk in type 2 diabetic patients

Journal of Diabetes Investigation

Lydia Foucan⁵  Suliya Maimaitiming¹  Laurent Larifla⁵  Segho Hedreville²  Jacqueline Deloumeaux⁵  Marie-Odile Joannes⁵  Anne Blanchet-Deverly⁵  Fritz-Line Velayoudom-Céphise⁵  Roberte Aubert¹  Roger Salamon⁴  Jean-Paul Donnet³ 

[1] INSERM, U695, Genetic determinants of type 2 diabetes and its vascular complications, Paris, France;Cardiology Unit, University Hospital of Pointe-à-Pitre, Guadeloupe, France;Diabetology Unit, University Hospital of Pointe-à-Pitre, Guadeloupe, France;Inserm U897, Bordeaux School of Public Health, Victor Segalen Bordeaux 2 University, Bordeaux, France;Research Group Clinical Epidemiology and Medicine, ECM/L.A.M.I.A EA 4540, University Hospital of Guadeloupe, University of Antilles and Guyane, Guadeloupe, France

关键词: Adiponectin;    Cardiometabolic risk;    Diabetes;   

DOI  :  10.1111/jdi.12133

来源: Wiley

【 摘 要 】

Abstract

Aims/Introduction

The aim of the present study was to examine the associations of rs2241766 (+45T>G), rs1501299 (+276G>T), rs17300539 (−11391G>A) and rs182052 (−10069G>A) in the adiponectin (Ad) gene with adiponectin concentrations, and concomitantly the association of these variants with cardiometabolic risk in type 2 diabetic patients of African ancestry.

Materials and Methods

A cross-sectional study of 200 patients was carried out. Concentrations of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms were measured. The four polymorphisms were genotyped.

Results

Decreased values were noted for total Ad in overweight, dyslipidemia and coronary artery disease (CAD), for HMW in overweight and dyslipidemia, for MMW in CAD, for LMW in dyslipidemia and CAD, for the percentage HMW/total in overweight, and for MMW:HMW ratio in patients without hypertriglyceridemic waist (HTGW). Significant associations were noted between total Ad, HMW, and HMW/total Ad and rs182052 under a dominant model (P = 0.04, P = 0.03 and P = 0.04, respectively), and between MMW and rs17300539 (P = 0.006). No significant difference in adiponectin concentrations was noted according to rs2241766 and rs1501299 genotypes. Patients carrying the rs2241766 G allele (TG+GG) had an increased risk of HTGW (odds ratio [OR] 3.1; P = 0.04) and of CAD (OR 3.3; P = 0.01). The odds of having low total adiponectin concentrations (<25th percentile: 3.49 ng/mL) for carrying the rs182052A allele (AA+GA) was: OR 0.40; P = 0.009. The single-nucleotide polymorphism associated with adiponectin levels was not concomitantly associated with cardiometabolic risk factors.

Conclusions

Adiponectin concentrations and ADIPOQ variants are implicated in the pathophysiological process leading to cardiovascular diseases, but the genetic effects seem to be independent of adiponectin concentrations in our Afro–Caribbean diabetic patients.

【 授权许可】

CC BY-NC   
© 2013 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.