Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Cardiovascular Diabetology

Original Investigation

Mark A Pereira¹  Sandhi M Barreto²  Estela ML Aquino³  Dora Chor⁴  Marina Bessel⁵  Bruce B Duncan⁵  Maria Inês Schmidt⁵  Noel T Mueller⁶ 

[1] Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA;Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil;Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil;National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;Postgraduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos n. 2600, sala 414, Porto Alegre, 90035-003, Porto Alegre, Rio Grande do Sul, Brazil;Postgraduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos n. 2600, sala 414, Porto Alegre, 90035-003, Porto Alegre, Rio Grande do Sul, Brazil;Department of Epidemiology, Columbia University, New York, NY, USA;Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA;

关键词: Puberty;    Menarche;    Diabetes;    Cardiometabolic risk;    Metabolic syndrome;    Obesity;    Brazil;    Nutrition transition;    Primordial prevention;    Epidemiology;   

DOI  :  10.1186/1475-2840-13-22

 received in 2013-11-19, accepted in 2014-01-13,  发布年份 2014

来源: Springer

【 摘 要 】

ObjectivesEarly menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have different life courses, is unknown. We tested the hypothesis that earlier menarche is associated with higher diabetes risk in Brazilian adults.MethodsWe used data from 8,075 women aged 35-74 years in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who had complete information on age at menarche, diabetes status, and covariates. Diabetes was defined based on self-reported physician diagnosis, medication use, and laboratory variables (fasting glucose, 2-hour glucose, and glycated hemoglobin). Poisson regression was used to generate risk ratios (RR) and 95% confidence intervals (CI).ResultsMenarche onset < 11 years [vs. 13-14 years (referent)] was associated with higher risk of diabetes (RR = 1.34; 95% CI: 1.14-1.57) after adjusting for sociodemographic factors, maternal education, maternal and paternal diabetes, and birth weight. This persisted after further control for BMI at age 20 years and relative leg length. Additionally, among those not taking diabetes medications, earlier menarche [<11 years vs. 13-14 years (referent)] was associated with higher % glycated hemoglobin (p < 0.001), alanine aminotransferase (p < 0.001), triglycerides (p < 0.001), C-reactive protein (p = 0.003), waist circumference (p < 0.001), and BMI measured at baseline exam (p < 0.001).ConclusionThese findings support the hypothesis that earlier menarche is associated with greater risk for adult diabetes and cardiometabolic disease in the Brazilian context.

【 授权许可】

CC BY   
© Mueller et al.; licensee BioMed Central Ltd. 2014