Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types

Journal of Cellular and Molecular Medicine

Dongli Song²  Dragos Cretoiu⁴  Minghuan Zheng²  Mengjia Qian²  Miaomiao Zhang²  Sanda M. Cretoiu⁴  Luonan Chen¹  Hao Fang³  Laurentiu M. Popescu⁴ 

[1] State Key Lab of Systems Biology, Chinese Academy of Science, Shanghai, China;Zhongshan Hospital, Fudan University Center for Clinical Bioinformatics, Shanghai Institute of Clinical Bioinformatics, Shanghai, China;Department of Anesthesiology, Zhongshan Hospital and Jinshan Hospital of Fudan University, Shanghai, China;Division of Cellular and Molecular Biology and Histology, Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

关键词: chromosome 4;    telocytes;    mesenchymal stem cells;    fibroblasts;    alveolar type II cells;    airway epithelial cells;    lymphocytes;   

DOI  :  10.1111/jcmm.12746

来源: Wiley

【 摘 要 】

Abstract

Telocytes (TCs) are new cellular entities of mesenchymal origin described almost ubiquitously in human and mammalian organs (www.telocytes.com). Different subtypes of TCs were described, all forming networks in the interstitial space by homo- and heterocellular junctions. Previous studies analysed the gene expression profiles of chromosomes 1, 2, 3, 17 and 18 of murine pulmonary TCs. In this study, we analysed by bioinformatics tools the gene expression profiles of chromosome 4 for murine pulmonary TCs and compared it with mesenchymal stem cells (MSCs), fibroblasts (Fbs), alveolar type II cells (ATII), airway basal cells, proximal airway cells, CD8(+) T cells from bronchial lymph nodes (T-BL) and CD8(+) T cells from lungs (T-L). Key functional genes were identified with the aid of the reference library of the National Center for Biotechnology Information Gene Expression Omnibus database. Seventeen genes were up-regulated and 56 genes were down-regulated in chromosome 4 of TCs compared with other cells. Four genes (Akap2, Gpr153, Sdc3 and Tbc1d2) were up-regulated between one and fourfold and one gene, Svep1, was overexpressed over fourfold. The main functional networks were identified and analysed, pointing out to a TCs involvement in cellular signalling, regulation of tissue inflammation and cell expansion and movement.

【 授权许可】

CC BY   
© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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