Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes

Journal of Cellular and Molecular Medicine

Xiaoru Sun⁴  Minghuan Zheng⁵  Miaomiao Zhang⁵  Mengjia Qian⁵  Yonghua Zheng⁴  Meiyi Li¹  Dragos Cretoiu³  Chengshui Chen²  Luonan Chen¹  Laurentiu M. Popescu³ 

[1]State Key Laboratory of Systems Biology, Chinese Academy of Science, Shanghai, China

[2]Department of Pulmonary Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

[3]Division of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

[4]Department of Pulmonary Medicine, Fudan University, Zhongshan Hospital, Shanghai Respiratory Research Institute, Shanghai, China

[5]Biomedical Research Center, Fudan University Zhongshan Hospital and Qinpu Hospital, Shanghai, China

关键词: chromosome 1;    genes;    lung;    telocytes;    mesenchymal stem cells;    fibroblasts;    alveolar type II cells;    airway epithelial cells;    lymphocytes;   

DOI  :  10.1111/jcmm.12302

来源: Wiley

【 摘 要 】

Abstract

Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps). Our previous study showed that TCs are distinct from fibroblasts (Fbs) and mesenchymal stem cells (MSCs) as concerns gene expression and proteomics. The present study explores patterns of mouse TC-specific gene profiles on chromosome 1. We investigated the network of main genes and the potential functional correlations. We compared gene expression profiles of mouse pulmonary TCs, MSCs, Fbs, alveolar type II cells (ATII), airway basal cells (ABCs), proximal airway cells (PACs), CD8⁺ T cells from bronchial lymph nodes (T-BL) and CD8⁺ T cells from lungs (T-LL). The functional and feature networks were identified and compared by bioinformatics tools. Our data showed that on TC chromosome 1, there are about 25% up-regulated and 70% down-regulated genes (more than onefold) as compared with the other cells respectively. Capn2, Fhl2 and Qsox1 were over-expressed in TCs compared to the other cells, indicating that biological functions of TCs are mainly associated with morphogenesis and local tissue homoeostasis. TCs seem to have important roles in the prevention of tissue inflammation and fibrogenesis development in lung inflammatory diseases and as modulators of immune cell response. In conclusion, TCs are distinct from the other cell types.

【 授权许可】

CC BY   
© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.