Resveratrol, a polyphenol phytoalexin, protects against doxorubicin‐induced cardiotoxicity

Journal of Cellular and Molecular Medicine

Jun Gu²  Wei Hu¹ 

[1] Department of Cardiology, Shanghai Minhang Hospital, Fudan University, Shanghai, China;Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

关键词: doxorubicin;    cardiotoxicity;    resveratrol;    ROS;    apoptosis;    autophagy;   

DOI  :  10.1111/jcmm.12633

来源: Wiley

【 摘 要 】

Abstract

Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration in apoptosis and autophagy. Interestingly, the use of resveratrol in combination with doxorubicin has been reported to prevent cardiac toxicity as well as to exert a synergistic effect against tumour cells both in vivo and in vitro. Thus, the aim of this review is to summarize current knowledge and to elucidate the protective effect of resveratrol in doxorubicin-induced cardiotoxicity.

【 授权许可】

CC BY   
© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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