The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats

Molecules

Aleksandar Rašković¹  Nebojša Stilinović¹  Jovanka Kolarović¹  Velibor Vasović¹  Saša Vukmirović¹ 

[1]¹Department of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia[2] height:6px

[3]"> ²Department of Hematology and Oncology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, 21000 Novi Sad, Serbia

关键词: silymarin;    silibinin;    doxorubicin;    cardiotoxicity;    hepatotoxicity;   

DOI  :  10.3390/molecules16108601

来源: mdpi

【 摘 要 】

Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of silymarin, rich in silibinin, at a dose of 60 mg/kg orally for a time-span of 12 days on doxorubicin induced toxicity in male Wistar rats. The in vivo model was used to explore whether silymarin could prevent damage of liver and heart tissue induced by doxorubicin administered every other day at dose of 1.66 mg/kg intraperitoneally for twelve days. In the study the change of body weight, ECG changes, biochemical parameters of oxidative stress, serum activity of alanine and aspartate transaminase, lactate dehydrogenase, creatine kinase and histological preparations of heart and liver samples of treated animals were examined. According to physiological, pharmacological, microscopic and biochemical results, we confirmed that at the examined dose, silymarin exhibits a protective influence on the heart and liver tissue against toxicity induced by doxorubicin.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.