Potential application of miRNAs as diagnostic and therapeutic tools in chronic pancreatitis

Journal of Cellular and Molecular Medicine

Liang-Hao Hu¹  Jun-Tao Ji¹ 

[1] Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China

关键词: chronic pancreatitis;    miRNA;    diagnosis;    therapeutic tools;    fibrosis;   

DOI  :  10.1111/jcmm.12603

来源: Wiley

【 摘 要 】

Abstract

Chronic pancreatitis (CP) is a progressive inflammatory disease typified by end-stage fibrosis. This disease can also increase the risk of pancreatic cancer. The associated diagnosis, pain and other complications further add to the burden of disease management. In recent years, significant progress has been achieved in identifying miRNAs and their physiological functions, including mRNA repression and protein expression control. Given the extensive effort made on miRNA research, a close correlation has been discovered between certain types of miRNAs and disease progression, particularly for tissue fibrosis. Designing miRNA-related tools for disease diagnosis and therapeutic treatments presents a novel and potential research frontier. In the current review, we discuss various miRNAs closely interacting with CP, as well as the possible development of targeted miRNA therapies in managing this disease.

【 授权许可】

CC BY   
© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.