Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

International Journal of Molecular Sciences

Jianfeng Zhong³  Yuan He¹  Wenjiang Chen³  Xiaorong Shui²  Can Chen³  Wei Lei³ 

[1] Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China; E-Mail:;Laboratory of Vascular Surgery, Guangdong Medical College, Zhanjiang 524001, China; E-Mail:;Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China; E-Mails:

关键词: acute myocardial infarction;    biomarkers;    diagnosis;    miRNA;    miR-19a;   

DOI  :  10.3390/ijms151120355

来源: mdpi

【 摘 要 】

Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.