Dehydrozingerone exerts beneficial metabolic effects in high‐fat diet‐induced obese mice via AMPK activation in skeletal muscle

Journal of Cellular and Molecular Medicine

Su Jin Kim¹  Hong Min Kim²  Eun Soo Lee²  Nami Kim¹  Jung Ok Lee¹  Hye Jeong Lee¹  Na Yeon Park³  Joo Yeon Jo³  Bo Young Ham³  Si Hyun Han³  Sun Hwa Park¹  Choon Hee Chung² 

[1] Department of Anatomy, Korea University College of Medicine, Seoul, South Korea;Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea;Seoul Science High School, Seoul, South Korea

关键词: AMPK;    curcumin analogue;    dehydrozingerone;    glucose uptake;    metabolism;   

DOI  :  10.1111/jcmm.12455

来源: Wiley

【 摘 要 】

Abstract

Dehydrozingerone (DHZ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high-fat diet-induced weight gain, lipid accumulation and hyperglycaemia in C57BL/6 mice and increased AMP-activated protein kinase (AMPK) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen-activated protein kinase (MAPK) signalling in an AMPK-dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ-induced glucose uptake. DHZ increased GLUT4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin-induced glucose uptake increased in DHZ-fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo. Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle.

【 授权许可】

CC BY   
© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.