The role of the cell–cell interactions in cancer progression

Journal of Cellular and Molecular Medicine

Katarzyna Kamińska³  Cezary Szczylik³  Zofia F. Bielecka³  Ewa Bartnik⁴  Camillo Porta¹  Fei Lian² 

[1] Medical Oncology, I.R.C.C.S. San Matteo University Hospital Foundation, Pavia, Italy;Emory University School of Medicine, Atlanta, GA, USA;Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland;Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland

关键词: cancer;    tumour microenvironment;    cell–cell interactions;    stromal cells;   

DOI  :  10.1111/jcmm.12408

来源: Wiley

【 摘 要 】

Abstract

In the field of cancer research, scientific investigations are based on analysing differences in the secretome, the proteome, the transcriptome, the expression of cell surface molecules, and the deregulation of signal transduction pathways between neoplastic and normal cells. Accumulating evidence indicates a crucial role in carcinogenesis concerning not only stromal cells but also normal cells from target organs and tissue where tumours emerge. The tumour microenvironment (TME) definitively plays an important role in regulating neighbouring cell behaviour. To date, limited attention has been focused upon interactions between cancer cells and normal cells. This review concentrates on the interactions between stromal and healthy cells from the TME in cancer development. In the article, the authors also describe mutations, genes and proteins expression pattern that are involved in tumour development in target organ.

【 授权许可】

CC BY   
© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.