A systems biology view of blood vessel growth and remodelling

Journal of Cellular and Molecular Medicine

Elizabeth A. Logsdon¹  Stacey D. Finley²  Aleksander S. Popel² 

[1] Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA;Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA

关键词: angiogenesis;    computational model;    mathematical model;    systems biology;    multi‐scale modelling;   

DOI  :  10.1111/jcmm.12164

来源: Wiley

【 摘 要 】

Abstract

Blood travels throughout the body in an extensive network of vessels – arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels – arterioles, venules and capillaries – can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis – the sprouting of new blood vessels – and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.