Invasive cancers are not necessarily from preformed in situ tumours — an alternative way of carcinogenesis from misplaced stem cells

Journal of Cellular and Molecular Medicine

Rui-An Wang¹  Zeng-Shan Li²  Hui-Zhong Zhang⁴  Ping-Ju Zheng³  Qin-Long Li²  Jian-Guo Shi²  Qing-Guo Yan²  Jing Ye²  Jing-Bo Wang²  Ying Guo²  Xiao-Feng Huang² 

[1] Department of Pathology of Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi Pr., China;State Key Lab of Cancer Biology, The Fourth Military Medical University, Xi'an, Shaanxi Pr., China;Department of Oncology, Chang'an Hospital, Xi'an, Shaanxi Pr., China;Department of Laboratory Medicine of Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi Pr., China

关键词: Carcinogenesis;    stem cell misplacement theory;    basement membrane;    breast cancer;    DCIS;    stroma;    quasi‐cancer;   

DOI  :  10.1111/jcmm.12078

来源: Wiley

【 摘 要 】

Abstract

Cancers are thought to be the result of accumulated gene mutations in cells. Carcinomas, which are cancers arising from epithelial tissues usually go through several stages of development: atypical hyperplasia, carcinoma in situ and then invasive carcinoma, which might further metastasize. However, we think that the present pathological data are enough to prove that there might be an alternative way of carcinogenesis. We propose that majority of invasive cancers arise in the connective tissue stroma de novo, from the misplaced epithelial stem cells which come to the wrong land of connective tissue stroma by accident. The in situ carcinomas, which are mostly curable, should not be considered genuine cancer, but rather as quasi-cancer. We design this new theory of carcinogenesis as the stem cell misplacement theory (SCMT). Our SCMT theory chains together other carcinogenesis theories such as the inflammation-cancer chain, the stem cell theory and the tissue organization field theory. However, we deny the pathway of somatic mutation theory as the major pathway of carcinogenesis.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

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