Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane

Polymers

Kentaro Hozumi¹  Jun Kumai²  Yuji Yamada²  Motoyoshi Nomizu² 

[1] Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;

关键词: basement membrane;    laminin;    peptides;    polysaccharide;   

DOI  :  10.3390/polym7020281

来源: mdpi

【 摘 要 】

The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellular functions for tissue engineering. We have developed laminin-derived active peptide-chitosan matrices as functional scaffolds. The biological activity of the peptides was enhanced when the peptides were conjugated to a chitosan matrix, suggesting that the peptide-chitosan matrix approach has an advantage for an active biomaterial. Further, the laminin peptide-chitosan matrices have the potential to mimic the basement membrane and are useful for tissue engineering as an artificial basement membrane.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.