Mechanobiology in cardiac physiology and diseases

Journal of Cellular and Molecular Medicine

Ken Takahashi²  Yoshihide Kakimoto¹  Kensaku Toda³ 

[1] Department of Medicine, Nagoya University, Nagoya, Japan;Department of Cardiovascular Physiology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;Department of Medicine, Okayama University, Okayama, Japan

关键词: mechanoelectric feedback;    mechanotransduction;    mechanosensitive ion channels;    arrhythmias;    ischaemic/reperfusion injury;    cardiogenesis;    mechanomedicine;   

DOI  :  10.1111/jcmm.12027

来源: Wiley

【 摘 要 】

Abstract

Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the Frank–Starling law of the heart and mechanoelectric feedback. We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels. We have also discussed the involvement of mechanosensitivity in heart diseases, such as arrhythmias, hypertrophy and ischaemic heart disease. Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.

【 授权许可】

CC BY   
© 2013 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.